Some individuals never have symptoms of this condition. Pdf pathophysiology of dyslipidemia in the metabolic. Engelking, in textbook of veterinary physiological chemistry third edition, 2015. It is made up of squamous epithelial cells, a layer of connective tissue, and a basement membrane. Hyperlipidemia means there is too much cholesterol in the blood cholesterol is a waxy fat molecule that the liver produces. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Obesity pathophysiology american association of clinical.
It is essential for healthy cell membranes, brain functioning, hormone. Cholesterol metaboilsm and pathophysiology of atherogenci dyslipidemia role of lipids cholesterol and lipoproteins e. Dyslipidemia pharmacotherapy quick guide accesspharmacy. The more hyperglycemic untreated niddm and insulindependent diabetic iddm patient have mild to moderate hypertriglyceridemia due to decreased adipose tissue and muscle lipoprotein lipase, lpl activity. The two major types of lipids found in the blood are triglycerides and cholesterol. Hyperlipidemia student health and counseling services. Hyperlipidemia type 3 genetic and rare diseases information. Hyperlipidemia is a medical term for abnormally high levels of fats lipids in the blood. Hyperlipidemia is a group of disorders of lipoprotein metabolism entailing elevated blood levels of certain forms of cholesterol and triglyceride. Pathophysiology of hyperlipidemia in diabetes mellitus.
Primary hyperlipidemia american college of cardiology. By age 60, every 5th man and 17th woman develops chd 1986 framingham data. Hyperlipidemia, dyslipidemia, and drug therapy also fat transport and metabolisim and pathophysiology of lipoprotein clincal importance of 1. This waxy white substance, contrary to its bad press, is an essential element for our health. Exclude secondary causes of dyslipidemia lifestyle modifications am fam physician 2010. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Upon physical examination you notice peripheral edema. The knowledge program is a database linked to our electronic medical record allowing capture of patient and clinician reported outcomes. Olives and olive oil in health and disease prevention, 2010.
Many lipoprotein abnormalities are seen in the untreated, hyperglycemic diabetic patient. Hyperlipidemia is considered one of the major risk factors causingcardiovascular diseases cvds. The primary defect in familial hypercholesterolemia is inability to bind ldl to the ldl receptor ldlr. Familial combined hyperlipidemia levels of cholesterol, triglycerides, or both are high and hdl is low it can also be related to a hormonal disease such as diabetes mellitus, hypothyroidism and cushings syndrome.
Dont forget to share this picture with others via facebook, twitter. Ppt hyperlipidemia chapter 23 powerpoint presentation. Report epidemiology and management of hyperlipidemia samantha karr, pharmd, fccp, bcps, bcacp. Cholesterol has no energy value, but serves as a building block for many important compounds such as vitamin d. Primary hyperlipidemia caused by environmental and genetic factors are by far the most frequent, accounting for 98% of all cases. Ppt hyperlipidemiadyslipidemia powerpoint presentation. Reducing the amount of saturated fat and cholesterol in your diet helps lower your blood cholesterol level. Autosomal dominant ldl receptor defects in heterozygotes, cholesterol levels are in the range of 6 12 mmoll, while in homozygotes, levels can be as high as 20 mmoll.
Ischemic cardiovascular and cerebrovascular events are leading causes of morbidity and mortality. Dec 28, 2015 hyperlipidemia, dyslipidemia, and drug therapy also fat transport and metabolisim and pathophysiology of lipoprotein clincal importance of 1. Hyperlipidemia is a condition in which there are elevated levels of cholesterol in the blood. The insulin resistancemetabolic syndrome mets is characterised by the variable coexistence of hyperinsulinaemia, obesity, dyslipidaemia, and hypertension. Diet reduce total fat intake to 30% or less of total energy and intake of dietary cholesterol to less than 300 mgday eat at least 5 portions of fruits and vegetables per day and.
Ppt hyperlipidemia chapter 23 powerpoint presentation free to download id. Key points obesity has a genetic basis as well as environmental and behavioral origins age contributes to a shift in balance between fat and muscle mass various negative feedback loops contribute to obesity increased caloric intake and reduced physical activity alters energy homeostasis, leading to a reduced metabolic rate alters neurohormonal signals, leading to increased appetite increased. That means they have a much greater chance of having a heart attack, even when theyre young. Mar 07, 2019 hyperlipidemia or dyslipidemia is also called high blood cholesterol. The tunica intima is the innermost layer and it is the layer which comes in direct contact with the blood. Pathophysiology of lipid disorders columbia university.
Nanda nursing diagnosis for hyperlipidemia was posted in december 25, 2014 at 5. Introduction hyperlipidemia is a condition of excess fatty. Each system has gaps and overlaps, and the transition further complicates efforts to organize the causes and. Vamsi 1, mohemmed sadiq 2 1sree vidyanikethan college of pharmacy, sree sainath nagar, tirupati, a. Cholesterol is a waxy fat molecule that the liver produces. Pmc free article rainwater dl, mitchell bd, mahaney mc, haffner sm. The pathophysiology of nephrotic hyperlipidemia is complex. Hyperlipidemia can be defined as elevation of serum total cholesterol tc andor triglyceride tg or reduced highdensity lipoprotein hdl cholesterol that predisposes to the development of atherosclerosis.
Aside from acute complications, care for people with diabetes mellitus requires measures to prevent the secondary complications of this disease. Cholesterol is a waxy white fatty molecule which is an essential part of every cell membrane. Describe the metabolic and physiologic responses to anemia, with emphasis on those that give rise to the clinical findings. O hyperlipidemia is an asymptomatic condition in which there are elevated amounts of fatty substances in the blood o triglycerides hyperlipidemia can lead to atherosclerosis, cad, stoke or mi. Just 150 minutes of moderateintensity aerobic exercise a week is enough to lower both cholesterol and high blood pressure. Dyslipidemia is closely associated with atherosclerosis and is a major causal factor in the development of ischemic diseases. Hyperlipidemia in childhood nephrotic syndrome springerlink. Pathophysiology of dyslipidaemia in the metabolic syndrome. Saturated fat and cholesterol in the food you eat make your blood cholesterol level go up.
The concept map of dyslipidemia hyperlipidemia starts with the definition. S9s148 for author information and disclosures, see end of text. A patient has had two blood pressure readings above 14090 two weeks apart. Hyperlipidemia is abnormally elevated levels of any or all lipids or lipoproteins in the blood lipids waterinsoluble molecules are transported in a protein capsule. Pdf pathophysiology of dyslipidemia in the metabolic syndrome. Cholesterol is an essential component found in all human cell membranes. Being overweight is a risk factor for heart disease. Pathophysiology of hypertension and hyperlipidemia.
Hyperlipidemia is most commonly associated with highfat diets, a sedentary lifestyle, obesity and diabetes. Although hyperglycemia is directly linked to microvascular disease of the eye and kidneys, several lines of evidence suggest that the relationship between macrovascular disease and hyperglycemia is not. Hyperlipidemia type 3 is an inherited condition that disrupts the normal breakdown of fats lipids in the body, causing a large amount of certain fatty materials to build up in the body. Secondary forms of dyslipidemia also exist, and several drug classes may elevate cholesterol levels eg, progestins, thiazide diuretics, glucocorticoids. Some drugs can also cause hyperlipidemia, including alcohol, diuretics, estrogens and betablockers. People who inherit the condition can get very high cholesterol. Quizlet flashcards, activities and games help you improve your grades. Autosomal dominant ldl receptor defects in heterozygotes, cholesterol levels are in the range of 6 12 mmoll, while in homozygotes, levels can be. A chronic inflammatory disease characterized by enzymatic destruction of the normal arterial skeleton largely elastin, collagen and smooth muscle, and replacement by disorganized collagen and elastin, cholesterol, and foam cells. Hyperlipidemia is the most important risk factor for atherosclerosis, which is the major cause of cardiovascular disease. Pathophysiology and treatment of hyperlipidemia study guide by lhaynes9 includes 47 questions covering vocabulary, terms and more.
Knowledge of pathophysiology of dyslipidemia has grown dramatically in. Pharmacologic treatment of hyperlipidemia in conjunction with therapeutic lifestyle changes can be used for both primary and secondary prevention of cardiovascular disease. These patients also have decreased hdl cholesterol levels associated with defective lpl catabolism of tgrich lipoproteins. Dyslipidemia is elevation of plasma cholesterol, triglycerides tgs, or both, or a low hdl cholesterol level that contributes to the development of atherosclerosis. Hyperlipidemia high blood fat the journal of clinical. Triglycerides are necessary to help transfer energy from food into body cells. Hyperlipidemia high levels of fats in the blood, such as cholesterol and triglycerides two main types of fats lipids are found in the blood, cholesterol and triglycerides lipoproteins.
I am going to talk about the pathophysiology of diabetes, and to some extent, dyslipidemia. The primary hyperlipidemia clinical topic collection gathers the latest guidelines, news, jacc articles, education, meetings and clinical images pertaining to its cardiovascular topical area all in one place for your convenience. Pathophysiology and treatment of hyperlipidemia quizlet. Pdf hyperlipidemia is a condition characterized by an elevation of any or all lipid profile andor lipoproteins in the blood. Dyslipidemia is a disorder of elevated or abnormal levels of lipids andor lipoproteins in the blood, characterized by high cholesterol, triglycerides tgs, or both, or low highdensity lipoprotein hdl level. Saturated fat is the main culprit, but cholesterol in foods also matters. The pathophysiology of hyperlipidemia can be studied under the. Clinical presentation the primary defect in familial hypercholesterolemia is the inability to bind ldl to the ldl receptor ldlr or, rarely, a defect of internalizing the ldlr complex into the cell after normal binding this leads to lack of ldl degradation by cells and unregulated biosynthesis of cholesterol, with total cholesterol and ldl cholesterol ldlc. We will start with the prevalence and epidemiology of diabetes. The adobe flash plugin is needed to view this content. Dec 29, 2016 hyperlipidemia type 3 is an inherited condition that disrupts the normal breakdown of fats lipids in the body, causing a large amount of certain fatty materials to build up in the body. Hyperlipidemia is an important characteristic of nephrotic syndrome ns.
Diabetes, low thyroid hormone levels, kidney disease and some other metabolic disorders cause hyperlipidemia. Cvds accounts for one third of total deaths around the world, it is believed that cvds will turn out to be the main cause of death and disability worldwide by the year 2020 1,2 hyperlipidemia isan increasein one or more of the plasma lipids, including triglycerides, cholesterol. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. This hd wallpaper nanda nursing diagnosis for hyperlipidemia has viewed by 2080 users. Hypercholesterolemia, elevated lowdensity lipoprotein, and low highdensity lipoprotein hdl are unequivocally linked to increased risk for coronary heart disease chd and cerebrovascular morbidity and mortality. The size of that capsule, or lipoprotein, determines its density. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Prevention and treatment of high cholesterol hyperlipidemia. Dyslipidemia endocrine and metabolic disorders merck. Elevation of plasma total cholesterol, or more specifically lowdensity lipoprotein cholesterol, is the major lipid abnormality in ns, although hypertriglyceridemia may develop as the disorder progresses. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. The insulin resistancemetabolic syndrome is characterised by the variable coexistence of hyperinsulinaemia, obesity, dyslipidaemia, and hypertension. Nanda nursing diagnosis for hyperlipidemia, download this wallpaper for free in hd resolution.
The pathogenesis of the syndrome has multiple origins, but obesity and sedentary lifestyle coupled with diet and still largely unknown genetic factors clearly interact to produce the syndrome. The classification of the dyslipidemias is transitioning from an older system based on phenotype to a newer system based on genetic or metabolic mechanism. Hyperlipidemia means there is too much cholesterol in the blood. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Influence of hypertension, diabetes, hyperlipidemia, and. Familial hypercholesterolemia, one form of hyperlipidemia, is the most common dominantly inherited genetic disorder in humans worldwide. Today, 65% of the adult american population is overweight body mass index greater than 25 kgm 2, 21% are obese body mass index greater than 30 kgm 2, and approximately a fourth of. Atherosclerosisis a pathologic processcharacterized by the accumulation of lipids, cholesterol and calciumand the development of fibrous plaques within the walls of large and medium arteries 21. Jul 26, 2017 hyperlipidemia is a medical term for abnormally high levels of fats lipids in the blood. The lipoprotein density and type of apolipoproteins it contains determines the fate of the particle and its influence on metabolism. Diagnosis is by measuring plasma levels of total cholesterol, tgs, and individual lipoproteins.
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